Cancer Therapy with Vinca Alkaloids
Int. J. Exp. Res. Rev., Vol. 7: 38-43 (2016)
Author: Madhushree Das Sarma
Abstract: Vinca alkaloids are well known antimitotic or antimicrotubule agents, originally derived from the medicinal plant Catharanthus roseus (Apocynacea) and other Vinca plants. They have a wide spectrum of anticancer activity both in vitro and in vivo. The most important members of this family are vinblastine and vincristine (naturally occurring), and their semisynthetic derivatives viz., vindesine, vinorelbine, vinflunine, which were approved by FDA as drugs in cancer therapy. They are used alone or in combination with other anticancer agents for the treatment of a variety of cancers including leukemias, lymphomas, advanced testicular cancer, breast and lung cancer and kaposi’s sarcoma. In this article, some cancer related relevant information of Vinca alkaloids are discussed.
Key words: Catharanthus roseus, Vinca alkaloids, chemotherapy, antimitotic
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